en جراحی دست / آرنج Hand surgery / Elbow پژوهشی Research Article <strong>Background:</strong> Avascular necrosis of the lunate or Kienböck&lrm; disease is a rare disorder with unknown etiology and challenging treatment.&nbsp;<br> Objectives: In this study, we evaluated the effects of local deferoxamine injection as an angiogenic molecule and core decompression to treat Kienböck&lrm; disease.<br> <strong>Methods:</strong> In a pilot clinical trial, 8 patients with stage I to IIIA of Kienböck&lrm; disease were treated with core decompression and local deferoxamine injection (0.5 mL 500 mg/mL). The outcome measures included wrist range of motions, pinch and grip strength, patient-rated &lrm;wrist/hand evaluation (PRWE), a short form of disabilities of the arm, shoulder, and hand (Quick-DASH), and visual analog scale (VAS) for pain. The assessment of lunate revascularization was also done by T1- and T2-weighted magnetic resonance imaging. All measurements were done before the intervention and 3, 6, and 12 months after the intervention.<br> <strong>Results: </strong>Wrist flexion, extension, ulnar and &lrm;radial deviation, and pinch and grip strength were continuously improved over the postoperative periods. These improvements were statistically significant. The mean final pinch and grip strength averaged 87.4% and 72.8% of the non-involved hand, respectively. PRWE, Quick-DASH, and VAS scores were also continuously and significantly improved over the study period. The lunate vascularization revealed a continuous improvement in 6(75%) patients.<br> <strong>Conclusion:</strong> Local deferoxamine injection in addition to core decompression could improve the radiologic and clinical outcomes of patients suffering from Kienböck&lrm; disease. Kienböck‎ disease, Lunate, Avascular necrosis, Deferoxamine 25 36 http://jros.iums.ac.ir/browse.php?a_code=A-10-94-3&slc_lang=en&sid=1 Farid Najd Mazhar fnajdmazhar@yahoo.com 10031947532846005842 10031947532846005842 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mojtaba Moztarzadeh maztarzadeh@gmail.com 10031947532846005843 10031947532846005843 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Ali Mohammad Sharifi sharifalim@gmail.com 10031947532846005844 10031947532846005844 No Department of Pharmacology, Razi Drug Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Alireza Mirzaei mirzaeialireza26@gmail.com 10031947532846005845 10031947532846005845 Yes Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.