en شانه / آرنج Shoulder / Elbow پژوهشی Research Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><b>Background:</b> The present study aimed to evaluate the outcomes of surgical debridement, irrigation, and placement of a drain for three weeks in combination with intravenous antibiotic therapy, in terms of the reduction of erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels. In addition, the type of microorganism responsible for infection was investigated.<br> <b>Methods:</b> This retrospective cross-sectional study included 14 patients identified from medical records at Shafa Yahyaeian and Iranmehr hospitals between 2017 and 2024. The effects of the surgical approach, as well as the type and duration of intravenous antibiotic therapy, on ESR and CRP levels were assessed. The causative microorganisms were identified through laboratory culture.<br> <b>Results:</b> ESR significantly decreased one week after the initiation of antibiotic therapy and at discharge (reductions of 93.7 mm/h and 24.36 mm/h, respectively, compared with preoperative values). CRP levels showed a significant reduction only at discharge (43.44 mg/L compared with preoperative levels), whereas the change observed one week after antibiotic initiation was not statistically significant. <i>Staphylococcus aureus</i> was identified as the causative pathogen in 20% of cases. On average, a combination of imipenem and vancomycin was administered for approximately two weeks in more than 40% of patients.<br> <b>Conclusion:</b> The combined use of prolonged drainage and a two-week regimen of intravenous imipenem plus vancomycin appears to be effective in significantly reducing ESR and CRP levels in patients with postoperative infection following open rotator cuff repair.</span></span></span></div> Rotator cuff tear, Open surgery, Secondary infection, C-reactive protein (CRP), Erythrocyte sedimentation rate (ESR), Intravenous antibiotics 0 0 http://jros.iums.ac.ir/browse.php?a_code=A-10-2740-1&slc_lang=en&sid=1 Morteza Nakhaei Amroodi drmna@yahoo.com 10031947532846008690 10031947532846008690 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Pouria Tabrizian tabrizian.pouria@gmail.com 10031947532846008691 10031947532846008691 Yes Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammadmehdi Mahdavifar Mahdavifarmohammadmehdi@gmail.com 10031947532846008692 10031947532846008692 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mehdi Karami mojtaba.at75@gmail.com 10031947532846008693 10031947532846008693 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Babak Hashemipour drbabakhashemi@gmail.com 10031947532846008694 10031947532846008694 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mojtaba Khajeh Alizadeh Attar mojtaba.attar75@gmail.com 10031947532846008695 10031947532846008695 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran