en جراحی زانو Knee surgery مروری Review Paper <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><b>Background:</b>&nbsp;Intra-articular injections, such as platelet-rich plasma (PRP) and hyaluronic acid (HA), are widely used to manage symptoms of knee osteoarthritis (OA). However, their effectiveness and superiority in patients with degenerative meniscal tears remain controversial. This systematic review aimed to compare the clinical outcomes of leukocyte-rich PRP (LR-PRP) and HA in patients with knee OA.<br> <b>Methods:</b>&nbsp;We searched PubMed/Medline, Scopus, Embase, and the Cochrane Library databases using relevant MeSH terms, following the <em><span style="background:white"><span style="color:black"><span style="font-style:normal">Preferred Reporting Items for Systematic Review</span></span></span></em><em><span style="background:white"><span style="color:black">s and Meta-Analyse</span></span></em><em><span style="background:white"><span style="color:black"><span style="font-style:normal">s </span></span></span></em>guidelines, to identify articles published between January 2010 and January 2026. Finally, eight studies, including randomized controlled trials and systematic reviews, were included in the qualitative analysis.<br> <b>Results:</b>&nbsp; Both LR-PRP and HA improved pain, joint function, and duration of therapeutic effect. However, PRP, particularly leukocyte-poor (LP-PRP) formulations, showed a tendency toward reduced reinjection requirements and greater long-term functional improvement. Both treatments were safe and well-tolerated; however, PRP demonstrated potential for more sustained clinical effects.<br> <b>Conclusion:</b>&nbsp;Based on moderate-to-high-certainty studies, the effects of LR-PRP and HA on clinical outcomes in patients with knee OA were similar. In the long term, PRP may be associated with a reduced need for reinjections and further improvement in functional outcomes. Due to variations in PRP preparation protocols and follow-up durations, it is recommended to conduct large-scale, long-term randomized controlled trials with standardized protocols to better determine the efficacy and optimize &nbsp;treatment strategies.</span></span></span></div> Knee osteoarthritis, Platelet-rich plasma (PRP), Hyaluronic acid (HA), Intra-articular injection, Joint function 0 0 http://jros.iums.ac.ir/browse.php?a_code=A-10-2741-1&slc_lang=en&sid=1 Ali Torkaman torkaman.a@iums.ac.ir 10031947532846008673 10031947532846008673 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohsen Fathi mohsenfathi71@yahoo.com 10031947532846008674 10031947532846008674 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Bushra Zareie shafabushra@gmail.com 10031947532846008675 10031947532846008675 No Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Omid Safaee Omid_safaee@yahoo.com 10031947532846008676 10031947532846008676 Yes Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran