Volume 11, Issue 1 (In-Press 2024)
JROS 2024, 11(1): 0-0 |
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Bagherifard A, Sahrai R, Mokhtari K, Yahyazedeh H. Therapeutic Impact of Platelet-Rich Plasma on Anterior Cruciate Ligament Injury: A Mini-Review. JROS 2024; 11 (1)
URL: http://jros.iums.ac.ir/article-1-2261-en.html
URL: http://jros.iums.ac.ir/article-1-2261-en.html
1- Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Baharestan Square, Tehran, IR, Iran.
2- Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Science, Tehran, Iran.
3- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
2- Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Science, Tehran, Iran.
3- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (45 Views)
Platelet-rich plasma (PRP) has emerged as a biological approach widely applied to enhance tissue repair and regeneration. This review explored the role of PRP in anterior cruciate ligament (ACL) reconstruction, focusing on PRP terminology, classification, growth factors, cellular origins, and optimizing platelet dosage in PRP therapies. With a variety of growth factors derived from distinct cellular sources, PRP positively influences tissue repair and regenerative processes. Molecular mechanisms and signaling pathways, including HIF-1α and p-mTOR/t-mTOR, are crucial in PRP-mediated tissue healing. Given PRP’s direct involvement in Osseo-tendinous convergence and ACL reconstruction, understanding the risk factors and contraindications is essential. The findings may contribute to optimizing PRP-based treatments for ACL regeneration.
Type of Study: Review Paper |
Subject:
Knee surgery
Received: 2024/11/26 | Accepted: 2024/12/28 | Published: 2024/02/13
Received: 2024/11/26 | Accepted: 2024/12/28 | Published: 2024/02/13
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