Volume 13, Issue 1 (Winter-In Press 2026)
JROS 2026, 13(1): 0-0 |
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Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (102 Views)
Intervertebral disc degeneration (IVDD) is a major contributor to low back pain and spinal disorders, representing a significant global health burden. Once considered a consequence of aging and mechanical stress, IVDD is now recognized as a multifactorial process involving complex molecular and cellular mechanisms. This narrative mini-review summarizes current insights into the pathophysiology of IVDD, focusing on inflammatory signaling, extracellular matrix degradation, oxidative stress, mitochondrial dysfunction, and cellular senescence. Understanding these interconnected pathways provides a foundation for the development of targeted and regenerative therapeutic strategies.
Keywords: Disc degeneration, Low back pain, Inflammatory signaling, Extracellular matrix degradation
Type of Study: Review Paper |
Subject:
Spine surgery
Received: 2026/05/4 | Accepted: 2026/05/4 | Published: 2026/02/24
Received: 2026/05/4 | Accepted: 2026/05/4 | Published: 2026/02/24
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