Journal of Research in Orthopedic Science

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Showing 3 results for Sarikhani

Evaluation of the Accuracy of Cup Positioning in Total Hip Arthroplasty Using the Antero-lateral Approach

Kaveh Gharanizadeh, Karim Pisoudeh, Mahmoodreza Sarikhani, Amir Aminian, Mohammadreza Bahaeddini,
Volume 9, Issue 3 (8-2022)

Abstract

Background: Total hip arthroplasty (THA) is a highly successful orthopedic procedure, recognized as the gold standard for addressing advanced osteoarthritis, with a projected global increase in performed cases.
Objectives: This study investigated the accuracy of cup positioning in patients undergoing THA using the anterolateral (AL) approach.
Methods: This cross-sectional study included patients undergoing ALTHA at Shafa Yahyaiyan Hospital in Tehran, affiliated with the Iran University of Medical Sciences, from 2018 to 2023. Post-operative radiological evaluations were conducted, and anteversion and inclination were assessed using established protocols. A safe zone for cup orientation was defined with an inclination angle of 40±10° and anteversion angle of 15±10°.
Results: Among 91 patients, the mean age was 51.14 years and 48 cases (52.7%) were male. Considering the safe zone for cup orientation, 69 patients (75.8%) fell within the inclination angle safe zone and 46(50.5%) were within the anteversion angle safe zone. However, no significant associations were found between age, gender, side of operation and the safe zones for anteversion and inclination.
Conclusion: The results indicated that the AL approach, as performed by experienced surgeons, achieved favorable cup positioning in the majority of patients, regardless of age and gender.

Advancements in Understanding and Managing Hypophosphatasia: From Clinical Spectrum and Diagnosis to Therapeutic Strategies

Roshanak Shams, Mozhdeh Zabihiyeganeh, Amir Aminian, Mahmoodreza Sarikhani,
Volume 9, Issue 4 (11-2022)

Abstract

Background: Hypophosphatasia (HPP) is a rare, inherited metabolic disorder caused by mutations in the gene responsible for producing the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP). The clinical spectrum of HPP ranges from severe, life-threatening forms in infants to milder forms in adults, primarily affecting dental health and bone integrity.
Objectives: This review aims to summarize the clinical manifestations and genetic underpinnings of HPP, discuss the diagnostic methodologies used to identify HPP and, highlight the therapeutic interventions available, with a focus on recent advancements.
Results: The review synthesizes information from clinical observations, radiographic findings, laboratory tests, and genetic screenings. It also evaluates recent literature on the pathophysiology and treatment of HPP, particularly the use of Asfotase alfa.
Discussion and Conclusion: Despite the existence of clear clinical markers, HPP often remains unrecognized for extended periods. Treatments like Asfotase alfa have significantly improved outcomes for severe cases in infants, children, and adults. However, questions about the optimal duration of treatment remain. Recent advancements have enhanced the understanding of HPP’s pathophysiology, particularly the role of persistently low serum alkaline phosphatase (AP) levels. Increased vigilance among healthcare professionals, including dentists, orthopedic surgeons, and rheumatologists, is crucial for timely diagnosis and management of HPP. The past decade has seen significant progress in understanding and treating HPP, offering new avenues for its management. This review encapsulates these advancements, providing a comprehensive overview of the evolving comprehension and approach towards this complex metabolic disorder.

Assessment of Refracture Rates and Associated Risk Factors Among Patients With Osteoporotic Fractures: A Cross-sectional Study

Mozhdeh Zabihiyeganeh, Aryan Rezaee, Amir Aminiana, Mohammadreza Bahaeddini, Mahmoodreza Sarikhani, Alireza Mirzaei,
Volume 10, Issue 1 (2-2023)

Abstract

Background: Osteoporosis is a skeletal disorder characterized by reduced bone strength leading to an increased risk for fracture. Patients with osteoporotic fractures are at an increased risk for refracture. Understanding the crucial importance of preventing recurring fractures to maintain physical activity and improve the quality of life (QoL) for individuals with osteoporosis underscores the necessity of precisely examining the factors that contribute to these fractures.
Objectives: This study evaluates the prevalence and risk factors associated with recurrent osteoporotic fractures, emphasizing the critical importance of targeted interventions for fracture prevention and overall well-being.
Methods: This observational prospective cohort study focused on patients with osteoporosis-related fractures attending the Fracture Liaison Service (FLS) Clinic of Shafa Yahyaeian Orthopedic Hospital in Tehran City, Iran, from 2021 to 2023. The hospital is affiliated with Iran University of Medical Sciences. The census-based sampling method included all eligible patients with a history of osteoporotic fractures. Demographic and clinical information were collected.
Results: Out of 1532 osteoporotic patients with a fracture history, 282(18.4%) experienced refractures between 2021 and 2023. Regression analysis demonstrated that higher age (P=0.005; OR=1.033) and female gender (P=0.010; OR=0.437) were the only factors significantly associated with refracture (R2=0.040). Fracture Recency evaluation indicated an mean interval of 2.8±2.5 (range: 0.5-12) years between the last two fractures. Furthermore, recurrent fractures after the index fracture occurred in 41% of patients during the first year.
Conclusion: The prevalence of refracture was 18.4%, with higher age and female gender as independent predictive factors. Notably, fracture recency was mainly observed in the first year.

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