Dr Amir Ebrahimzadeh Babaki, Dr Fahimeh Ebrahimzadeh Babaki, Dr Mohammad Reza Mortazavizadeh,
Volume 9, Issue 4 (11-2022)
Background and Objectives: Osteosarcoma (OS) is the most common cause of limb loss due to cancers. This study determines the mean survival time in patients with OS and prognostic factors.
Methods: This retrospective study was conducted on patients with OS who were referred to Shah Vali Hospital, Yazd, Iran, from 2004 to 2018. The data on patient-related factors (age and sex), tumor-related factors (recurrence, recurrence site, and metastasis), and living status were obtained and analyzed.
Results: Overall, 29 patients were included, of which 21(72.4%) were male. The mean age of patients was 21.3±8.4 (age range of 8-42) years. The tumor site was the lower limb in 23 patients (79.3%), the upper limbs in 4 patients (13.8%), and the axial in 2 patients (6.9%). Meanwhile, 13(44.8%) patients died due to OS, and one (6.9%) died for other reasons. The mean survival time in the subjects was 83.1±14.71 months. The 1-year survival of patients was nearly 90%, 3-year survival was about 64%, and 5-year survival was 40%. Also, 7(24.1%) patients had primary metastasis. The mean survival period was 22.25 months in patients with primary metastasis and 98.87 months in patients without primary metastasis (P=0.011). Among the patients, 15(51.7%) had a recurrence, of which 6(20.7%) were local, and 9(31%) were distant recurrences. The mean survival period after the recurrence of patients was 21.27±5.07 months.
Conclusion: The mean survival period, according to sex, age, recurrence, and recurrence site, was not significant; however, it was significant according to metastasis.
