RT - Journal Article T1 - Severe Osteoarthritis of the Knee as an Early Symptom of Alkaptonuria: A Case Report JF - iums-jros YR - 2016 JO - iums-jros VO - 3 IS - 1 UR - http://jros.iums.ac.ir/article-1-168-en.html SP - 0 EP - 0 K1 - Alkaptonuria K1 - Ochronosis K1 - Knee Arthroplasty K1 - Journey II CR AB - Introduction: Alkaptonuria (AKU) is a very rare disease and occurs due to the deficiency of the enzyme homogentisate1, 2-dioxygenase (HGD) which results in ochronosis, a term used to describe the dark pigmentation of the tissues. Alkaptonuria affects mostly the knee joint followed by the hip as major weight bearing joints, where the life quality of such patients is severely affected. LA eng UL http://jros.iums.ac.ir/article-1-168-en.html M3 10.17795/soj-4547 ER -