TY - JOUR JF - iums-jros JO - J. Res. Orthop. Sci. VL - 3 IS - 1 PY - 2016 Y1 - 2016/2/01 TI - Severe Osteoarthritis of the Knee as an Early Symptom of Alkaptonuria: A Case Report TT - N2 - Introduction: Alkaptonuria (AKU) is a very rare disease and occurs due to the deficiency of the enzyme homogentisate1, 2-dioxygenase (HGD) which results in ochronosis, a term used to describe the dark pigmentation of the tissues. Alkaptonuria affects mostly the knee joint followed by the hip as major weight bearing joints, where the life quality of such patients is severely affected. SP - 0 EP - 0 AU - Franz, Alois AU - Abusafieh, Mohammed AD - Department of Orthopedics, Trauma and Hand Surgery, St. Marien Hospital, Siegen, Germany KW - Alkaptonuria KW - Ochronosis KW - Knee Arthroplasty KW - Journey II CR UR - http://jros.iums.ac.ir/article-1-168-en.html DO - 10.17795/soj-4547 ER -