en جراحی زانو Knee surgery پژوهشی Research Article <strong>Background</strong>: The most clinical manifestation of hemophilia, as a congenital bleeding disorder, is the Intra-articular hemorrhage. The treatment of acute hemarthrosis with a sufficient amount of factor replacement will return the joint to the normal status.<br> <strong>Objectives</strong>: This study aimed to evaluate the efficacy of platelet-rich plasma in the treatment of hemophilic arthropathy patients to reduce and improve their pain and physical function.<br> <strong>Methods</strong>: Consecutive patients with hemophilic arthropathy were included in a self-control open-label trial in Mofid Children&rsquo;s Hospital, Tehran, Iran. All participants received three platelet-rich plasma injections given two&nbsp;weeks apart. Also, the seriate self-reported and objective clinical outcomes were evaluated before and three months after the treatment.&nbsp;<br> <strong>Results</strong>: A total of 11 patients with hemophilic arthropathy involving 14 joints received three injections of platelet-rich plasma at 2-week intervals, at our center. All patients were evaluated with a visual analog scale, the hemophilia joint health score, and the range of motion, and bleeding events, before and after the treatment. Finally, 9 boys (81.8%) and 2 girls (18.2%) completed the study. The mean age of the participants was 14.7 years (range, 9-19 years). In all patients, statistically significant improvements were noted on all evaluated measures.<br> <strong>Conclusion</strong>: Platelet-rich plasma therapy is a reasonable and minimally invasive procedure that includes beneficial chondro-regenerative properties. Arthropathies, Platelet-Rich plasma, Prophylaxis, Synovitis, Hemophilia 165 168 http://jros.iums.ac.ir/browse.php?a_code=A-10-693-1&slc_lang=en&sid=1 Hoorieh Davoodabadi peshgi64@gmail.com 10031947532846003928 10031947532846003928 No Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern’s Health, Shahid Beheshti University of Medical Sciences, Tehran. Fatemeh Malek fmalek7721@gmail.com 10031947532846003929 10031947532846003929 No Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern’s Health, Shahid Beheshti University of Medical Sciences, Tehran. Behnaz Habibpanah behnaz_panah@yaho.com 10031947532846003930 10031947532846003930 Yes Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern’s Health, Shahid Beheshti University of Medical Sciences, Tehran. Abolfazl Ghoojani a.ghoojani@gmail.com 10031947532846003931 10031947532846003931 No Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern’s Health, Shahid Beheshti University of Medical Sciences, Tehran.