en جراحی زانو Knee surgery مروری Review Paper <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;">Platelet-rich plasma (PRP) has emerged as a biological approach widely applied to enhance tissue repair and regeneration. This review explored the role of PRP in anterior cruciate ligament (ACL) reconstruction, focusing on PRP terminology, classification, growth factors (GFs), cellular origins, and optimizing platelet dosage in PRP therapies. With a variety of GFs derived from distinct cellular sources, PRP positively influences tissue repair and regenerative processes. Molecular mechanisms and signaling pathways, including HIF-1&alpha; and p-mTOR/t-mTOR, are crucial in PRP-mediated tissue healing. Given PRP&rsquo;s direct involvement in Osseo-tendinous convergence and ACL reconstruction, understanding the risk factors and contraindications is essential. The findings may contribute to optimizing PRP-based treatments for ACL regeneration.</span></span></span></div> Platelet-rich plasma (PRP), Anterior cruciate ligament (ACL), Tissue regeneration, Platelet dosage, Signaling pathway 1 14 http://jros.iums.ac.ir/browse.php?a_code=A-10-217-1&slc_lang=en&sid=1 Abolfazl Bagherifard Bagherifd@gmail.com 10031947532846007861 10031947532846007861 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran. Reza Sahrai Rezasahrai057@gmail.com 10031947532846007862 10031947532846007862 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran. Khatere Mokhtari khatere_mokhtari@yahoo.com 10031947532846007863 0009-0002-1179-4769 No Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran. Hooman Yahyazedeh Yahyazadehhooman@yahoo.com 10031947532846007864 10031947532846007864 Yes Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran.