en جراحی زانو Knee surgery مروری Review Paper <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Background</strong>: Intra-articular injections, such as platelet-rich plasma (PRP) and hyaluronic acid (HA), are widely used to manage symptoms of knee osteoarthritis (OA). However, their effectiveness and superiority in patients with degenerative meniscal tears remain controversial.&nbsp;<br> <strong>Objectives</strong>: This systematic review aimed to compare the clinical outcomes of leukocyte-rich PRP (LR-PRP) and HA in patients with knee OA. &nbsp;<br> <strong>Methods</strong>: We searched PubMed/Medline, Scopus, Embase, and the Cochrane Library databases using relevant MeSH terms, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, to identify articles published between January 2010 and January 2026. Finally, eight studies, including randomized controlled trials and systematic reviews, were included in the qualitative analysis.&nbsp;<br> <strong>Results</strong>: Both LR-PRP and HA improved pain, joint function, and duration of therapeutic effect. However, PRP, particularly leukocyte-poor (LP-PRP) formulations, showed a tendency toward reduced reinjection requirements and greater long-term functional improvement. Both treatments were safe and well-tolerated; however, PRP demonstrated potential for more sustained clinical effects.<br> <strong>Conclusion</strong>: Based on moderate-to-high-certainty studies, the effects of LR-PRP and HA on clinical outcomes in patients with knee OA were similar. In the long term, PRP may be associated with a reduced need for reinjections and further improvement in functional outcomes. Due to variations in PRP preparation protocols and follow-up durations, it is recommended to conduct large-scale, long-term randomized controlled trials with standardized protocols to better determine the efficacy and optimize treatment strategies.</span></span></span></div> Knee osteoarthritis (OA), Platelet-rich plasma (PRP), Hyaluronic acid (HA), Intra-articular injection, Joint function 161 170 http://jros.iums.ac.ir/browse.php?a_code=A-10-2741-1&slc_lang=en&sid=1 Ali Torkaman torkaman.a@iums.ac.ir 10031947532846008826 10031947532846008826 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Mohsen Fathi mohsenfathi71@yahoo.com 10031947532846008827 0009-0001-8062-2701 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Bushra Zareie shafabushra@gmail.com 10031947532846008828 10031947532846008828 No Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Omid Safaee Omid_safaee@yahoo.com 10031947532846008829 0009-0002-6175-1572 Yes Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.