Volume 7, Issue 4 (11-2020)                   J. Res. Orthop. Sci. 2020, 7(4): 165-168 | Back to browse issues page


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Davoodabadi H, Malek F, Habibpanah B, Ghoojani A. The Efficacy of Platelet-Rich Plasma in the Treatment of Hemophilic Arthropathy. J. Res. Orthop. Sci.. 2020; 7 (4) :165-168
URL: http://jros.iums.ac.ir/article-1-2090-en.html
1- Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Childern’s Health, Shahid Beheshti University of Medical Sciences, Tehran.
Abstract:   (99 Views)
Background: The most clinical manifestation of hemophilia, as a congenital bleeding disorder, is the Intra-articular hemorrhage. The treatment of acute hemarthrosis with a sufficient amount of factor replacement will return the joint to the normal status.
Objectives: This study aimed to evaluate the efficacy of platelet-rich plasma in the treatment of hemophilic arthropathy patients to reduce and improve their pain and physical function.
Methods: Consecutive patients with hemophilic arthropathy were included in a self-control open-label trial in Mofid Children’s Hospital, Tehran, Iran. All participants received three platelet-rich plasma injections given two weeks apart. Also, the seriate self-reported and objective clinical outcomes were evaluated before and three months after the treatment. 
Results: A total of 11 patients with hemophilic arthropathy involving 14 joints received three injections of platelet-rich plasma at 2-week intervals, at our center. All patients were evaluated with a visual analog scale, the hemophilia joint health score, and the range of motion, and bleeding events, before and after the treatment. Finally, 9 boys (81.8%) and 2 girls (18.2%) completed the study. The mean age of the participants was 14.7 years (range, 9-19 years). In all patients, statistically significant improvements were noted on all evaluated measures.
Conclusion: Platelet-rich plasma therapy is a reasonable and minimally invasive procedure that includes beneficial chondro-regenerative properties.
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Type of Study: Research Article | Subject: Knee surgery
Received: 2020/01/23 | Accepted: 2020/08/23 | Published: 2020/11/1

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