Volume 11, Issue 1 (2-2024)
JROS 2024, 11(1): 1-14 |
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Bagherifard A, Sahrai R, Mokhtari K, Yahyazedeh H. Therapeutic Impact of Platelet-rich Plasma on Anterior Cruciate Ligament Injury: A Mini-review. JROS 2024; 11 (1) :1-14
URL: http://jros.iums.ac.ir/article-1-2261-en.html
URL: http://jros.iums.ac.ir/article-1-2261-en.html
1- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran. & Department of Orthopedics, Shafayahyaeian Hospital, School of Medicine, Iran University of Medical Sciences,Tehran, Iran.
2- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran.
3- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
4- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran. & Department of Orthopedic Surgery, Faculty of Medicine, Farhikhtegan Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
2- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran.
3- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
4- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Science, Tehran, Iran. & Department of Orthopedic Surgery, Faculty of Medicine, Farhikhtegan Hospital, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran.
Abstract: (145 Views)
Platelet-rich plasma (PRP) has emerged as a biological approach widely applied to enhance tissue repair and regeneration. This review explored the role of PRP in anterior cruciate ligament (ACL) reconstruction, focusing on PRP terminology, classification, growth factors (GFs), cellular origins, and optimizing platelet dosage in PRP therapies. With a variety of GFs derived from distinct cellular sources, PRP positively influences tissue repair and regenerative processes. Molecular mechanisms and signaling pathways, including HIF-1α and p-mTOR/t-mTOR, are crucial in PRP-mediated tissue healing. Given PRP’s direct involvement in Osseo-tendinous convergence and ACL reconstruction, understanding the risk factors and contraindications is essential. The findings may contribute to optimizing PRP-based treatments for ACL regeneration.
Keywords: Platelet-rich plasma (PRP), Anterior cruciate ligament (ACL), Tissue regeneration, Platelet dosage, Signaling pathway
Type of Study: Review Paper |
Subject:
Knee surgery
Received: 2023/11/26 | Accepted: 2023/12/28 | Published: 2024/02/1
Received: 2023/11/26 | Accepted: 2023/12/28 | Published: 2024/02/1
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