Mendeley  

Zotero  

Bagherifard A, Mokhtari K, Yahyazedeh H. Molecular Mechanisms and Bone Dynamics in Osteomyelitis: A Mini-review. JROS 2024; 11 (2) :55-76
URL: http://jros.iums.ac.ir/article-1-2267-en.html

Osteomyelitis (OM) is a bone infection typically caused by bacterial pathogens, most commonly Staphylococcus aureus, leading to both acute and chronic inflammation within the bone. The molecular mechanisms underlying OM are complex and involve an interplay between immune cells, bacteria, and bone-residing cells. This mini-review discusses the molecular processes involved in OM, including the role of pro-inflammatory cytokines, osteoclast activation, and disruption of bone homeostasis. The infection induces a cascade of inflammatory responses that not only contribute to the direct destruction of bone tissue but also impair bone repair. The review also highlights how changes in bone dynamics, such as osteoclastic bone resorption and the failure of osteoblastic bone formation, play a critical role in the progression of OM. Understanding these molecular and cellular interactions is crucial for developing more effective therapeutic strategies and targeted interventions to combat OM.