Volume 10, Issue 2 (In-Press 2023)
JROS 2023, 10(2): 0-0 |
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Saffarpour S, Mirzaie A, Raja F, Tehrani-Banihashemi A, Heydari P, Zareie B et al . Serum Inflammatory Markers in Osteoporotic Fracture Patients: A Survey in the Fracture Liaison Service at ShafaYahyaeian Orthopedic Hospital, Tehran, Iran. JROS 2023; 10 (2)
URL: http://jros.iums.ac.ir/article-1-2228-en.html
URL: http://jros.iums.ac.ir/article-1-2228-en.html
Sepideh Saffarpour1 
, Alireza Mirzaie2 , Fatemeh Raja1 , Arash Tehrani-Banihashemi3 , Pegah Heydari1 , Bushra Zareie1 , Mozhdeh Zabihiyeganeh 1
, Alireza Mirzaie2 , Fatemeh Raja1 , Arash Tehrani-Banihashemi3 , Pegah Heydari1 , Bushra Zareie1 , Mozhdeh Zabihiyeganeh 1
1- Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
3- Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota, USA.
3- Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, Community and Family Medicine Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract: (52 Views)
Background: Fracture Liaison Service (FLS) is a healthcare model aimed at preventing re-fractures by diagnosing, investigating, and treating osteoporosis, as soon as possible, in patients with the history of previous osteoporotic fragility fracture.As per the literature, secondary causes of osteoporosis can affect two-thirds of older men, and 30% of postmenopausal women. Monoclonal gammopathy of uncertain significance, Multiple myeloma and chronic infectious diseases are important causes of secondary osteoporosis andpatients can present with fragility fracture as a first presentation of underlying disease.Measurement of inflammatory markers, such as ESR (erythrocyte sedimentation rate) and CRP (C-reactive protein), has important role in assessing secondary osteoporosis.The measurement of inflammatory markers, while being easy to measure and affordable, can be helpful in guiding the team to screen for secondary osteoporosis.
Objective:To analyze ESR and CRP levels in patients with osteoporotic fractures and to assess their associations with patients’ demographic and clinical characteristics.
Materials and Methods:In this retrospective cross-sectional study, 1979 patients who were enrolled in the FLS clinic of ShafaYahyaeian Orthopedic Hospital between October 2020 and May 2023 were included.The main outcome was determining the percentage of patients with high ESR and CRP levels and investigating the relationship between these markers and the demographic/ clinical variables. The data were analyzed using SPSS version 26 software.
Results: Out of 1979 patients, 32% had elevated ESR levels, and 40% had elevated CRP levels. Females, older patients, those with higher BMI (body mass index), and patients with lower BMD (bone mass density) in the femoral neck, hip, and radius had significantly higher ESR levels. Higher CRP levels were significantly associated with male sex, lower BMI, lower BMD in the radius, and lower serum vitamin D. Necessary investigations were done to rule out the causes of secondary osteoporosis, including malignancy and infection, in patients who had elevated ESR and CRP, and no cases of secondary osteoporosis were found.
Conclusion: Although about one third of our patients had high ESR or CRP, no case of secondary osteoporosis was identified, suggesting not to check inflammatory factors in the acute phase of fracture. The high level of inflammatory factors in the early phase of fracture may be attributed to physiological process of fracture healing.
Objective:To analyze ESR and CRP levels in patients with osteoporotic fractures and to assess their associations with patients’ demographic and clinical characteristics.
Materials and Methods:In this retrospective cross-sectional study, 1979 patients who were enrolled in the FLS clinic of ShafaYahyaeian Orthopedic Hospital between October 2020 and May 2023 were included.The main outcome was determining the percentage of patients with high ESR and CRP levels and investigating the relationship between these markers and the demographic/ clinical variables. The data were analyzed using SPSS version 26 software.
Results: Out of 1979 patients, 32% had elevated ESR levels, and 40% had elevated CRP levels. Females, older patients, those with higher BMI (body mass index), and patients with lower BMD (bone mass density) in the femoral neck, hip, and radius had significantly higher ESR levels. Higher CRP levels were significantly associated with male sex, lower BMI, lower BMD in the radius, and lower serum vitamin D. Necessary investigations were done to rule out the causes of secondary osteoporosis, including malignancy and infection, in patients who had elevated ESR and CRP, and no cases of secondary osteoporosis were found.
Conclusion: Although about one third of our patients had high ESR or CRP, no case of secondary osteoporosis was identified, suggesting not to check inflammatory factors in the acute phase of fracture. The high level of inflammatory factors in the early phase of fracture may be attributed to physiological process of fracture healing.
Type of Study: Research Article |
Subject:
Rheumatology
Received: 2024/03/3 | Accepted: 2024/09/14 | Published: 2023/05/8
Received: 2024/03/3 | Accepted: 2024/09/14 | Published: 2023/05/8
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