Volume 11, Issue 4 (11-2024)
JROS 2024, 11(4): 207-212 |
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Sobhani A, Fathi A, Shariatzadeh H, Babaei S, Seifi Ashkezari A, Amiri S, et al . Effects of Vitamin C and Oxycodone on Prevention of Complex Regional Pain After Surgically Treated Distal Radius Fractures. JROS 2024; 11 (4) :207-212
URL: http://jros.iums.ac.ir/article-1-2285-en.html
URL: http://jros.iums.ac.ir/article-1-2285-en.html
Amir Sobhani1 
, Amin Fathi1 , Hooman Shariatzadeh2 , Shima Babaei3 , AliAkbar Seifi Ashkezari4 , Shayan Amiri1 , Taghi Aghajanlou1 , Sina Moghimi2 , Ahmad Hemat Yar5
, Amin Fathi1 , Hooman Shariatzadeh2 , Shima Babaei3 , AliAkbar Seifi Ashkezari4 , Shayan Amiri1 , Taghi Aghajanlou1 , Sina Moghimi2 , Ahmad Hemat Yar5
1- Department of Orthopedic Surgery, Rasul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Orthopedic Surgery, Shafayahyaeian Hospital, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Pharmacy, Faculty of Pharmacy, Eastern Mediterranean University (EMU), Famagusta, Cyprus.
4- School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
5- Department of Orthopedic Surgery, Shohada-e Haft-e Tir Hospital, Tehran, Iran.
2- Department of Orthopedic Surgery, Shafayahyaeian Hospital, Iran University of Medical Sciences, Tehran, Iran.
3- Department of Pharmacy, Faculty of Pharmacy, Eastern Mediterranean University (EMU), Famagusta, Cyprus.
4- School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
5- Department of Orthopedic Surgery, Shohada-e Haft-e Tir Hospital, Tehran, Iran.
Abstract: (22 Views)
Background: Complex regional pain syndrome (CRPS) is a chronic and debilitating condition that often occurs following distal radius fractures. Severe pain, vasomotor and sudomotor changes, swelling, and functional impairments characterize this syndrome. Given the high costs and psychological burden associated with this condition, preventive and therapeutic interventions, such as vitamin C and oxycodone, have drawn considerable attention.
Objectives: This study aimed to evaluate the effects of vitamin C and oxycodone on the incidence and severity of CRPS symptoms in patients with distal radius fractures treated with surgical pinning and casting.
Methods: This randomized, double-blind clinical trial was conducted on 120 patients at three major hospitals in Tehran City, Iran. The patients were divided into three groups: The vitamin C group (500 mg daily for 8 weeks), the oxycodone group (5-10 mg daily based on weight for 2 weeks), and the placebo group. Assessments included pain intensity (visual analog scale [VAS]), joint functionality (Quick DASH), and CRPS symptoms at weeks 2, 4, 6, and 8.
Results: The vitamin C group demonstrated significant reductions in CRPS symptoms (e.g. swelling, sensitivity to cold) and improved joint functionality. The oxycodone group showed the greatest reduction in acute pain during the early phases of treatment, but had a limited effect on CRPS symptoms. The placebo group exhibited the least improvement across all measures.
Conclusion: Vitamin C can be recommended as an effective preventive strategy for managing CRPS. Oxycodone is beneficial for controlling acute pain but requires cautious long-term use. Combining these two interventions may yield optimal results.
Objectives: This study aimed to evaluate the effects of vitamin C and oxycodone on the incidence and severity of CRPS symptoms in patients with distal radius fractures treated with surgical pinning and casting.
Methods: This randomized, double-blind clinical trial was conducted on 120 patients at three major hospitals in Tehran City, Iran. The patients were divided into three groups: The vitamin C group (500 mg daily for 8 weeks), the oxycodone group (5-10 mg daily based on weight for 2 weeks), and the placebo group. Assessments included pain intensity (visual analog scale [VAS]), joint functionality (Quick DASH), and CRPS symptoms at weeks 2, 4, 6, and 8.
Results: The vitamin C group demonstrated significant reductions in CRPS symptoms (e.g. swelling, sensitivity to cold) and improved joint functionality. The oxycodone group showed the greatest reduction in acute pain during the early phases of treatment, but had a limited effect on CRPS symptoms. The placebo group exhibited the least improvement across all measures.
Conclusion: Vitamin C can be recommended as an effective preventive strategy for managing CRPS. Oxycodone is beneficial for controlling acute pain but requires cautious long-term use. Combining these two interventions may yield optimal results.
Keywords: Complex regional pain syndrome (CRPS), Prevention, Distal radius fractures, Vitamin C, Oxycodone
Type of Study: Research Article |
Subject:
Hand surgery / Elbow
Received: 2025/06/9 | Accepted: 2025/09/27 | Published: 2024/11/20
Received: 2025/06/9 | Accepted: 2025/09/27 | Published: 2024/11/20
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