Volume 12, Issue 1 (Winter 2025)
JROS 2025, 12(1): 1-12 |
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Tabrizian P, Nakhaei Amroodi M, Mokhtari K, Bahaeddini M, Baniasadi M. Genetic Contributions to Bone Health and Disease: A Mini-review. JROS 2025; 12 (1) :1-12
URL: http://jros.iums.ac.ir/article-1-2293-en.html
URL: http://jros.iums.ac.ir/article-1-2293-en.html
Pouria Tabrizian1 
, Morteza Nakhaei Amroodi1 , Khatere Mokhtari2 , Mohammadreza Bahaeddini1 , Mojtaba Baniasadi1
, Morteza Nakhaei Amroodi1 , Khatere Mokhtari2 , Mohammadreza Bahaeddini1 , Mojtaba Baniasadi1
1- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
2- Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (157 Views)
Bone health is a complex process governed by the interplay of genetic and environmental factors. This mini-review explores the contribution of genetic factors to bone health, with particular focus on their role in bone mineral density (BMD), osteoporosis, and metabolic bone diseases. BMD and fracture risk, which are influenced by genetics, exhibit high heritability, with estimates ranging from 50% to 85%. Significant genetic effects have been observed, particularly in the axial skeleton. Furthermore, genetic factors impact metabolic bone diseases, which can be monogenic or polygenic. Monogenic disorders, such as osteogenesis imperfecta, are linked to mutations in specific genes, while polygenic disorders involve multiple genetic variations that interact with environmental factors. The identification of genetic loci responsible for these conditions has provided insight into their molecular pathogenesis, offering potential therapeutic targets. Understanding genetic contributions to bone health is crucial for developing personalized treatment strategies for metabolic bone diseases.
Keywords: Bone health, Genetics, Bone mineral density (BMD), Metabolic bone diseases, Genetic mutations, Monogenic disorders, Polygenic traits
Type of Study: Review Paper |
Subject:
Shoulder / Elbow
Received: 2024/07/4 | Accepted: 2024/12/13 | Published: 2025/02/1
Received: 2024/07/4 | Accepted: 2024/12/13 | Published: 2025/02/1
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