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mohammadi M, jalali A. A Brief Review of the Role of Ghrelin in Osteoarthritis. JROS 2025; 12 (3) :109-116
URL: http://jros.iums.ac.ir/article-1-2299-en.html

Ghrelin, often referred to as the hunger hormone, is a peptide produced primarily in the stomach that plays an essential role in managing energy balance, appetite, and the release of growth hormone. It exhibits effects similar to growth hormone-releasing hormone and can effectively stimulate the secretion of growth hormone (GH) from pituitary GH cells. As a result, ghrelin is thought to contribute to the promotion of bone growth and development. Recent evidence indicates that ghrelin may also be involved in the regulation of inflammatory and degenerative processes within joint tissues. Osteoarthritis (OA) is a common chronic degenerative disease characterized by degeneration in the joints and subsequent destruction of cartilage and bone, yet much remains to be elucidated regarding its molecular mechanism. In this article, the roles of ghrelin in osteoarthritis were summarized to reveal the potential effects of ghrelin as a key target in the treatment of osteoarthritis.