Volume 13, Issue 1 (Winter 2026)
JROS 2026, 13(1): 5-8 |
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Farahini H, Khadem M. Synovial Macrophage Polarization in Knee Osteoarthritis: A Narrative Mini-review of an Emerging Biological Target. JROS 2026; 13 (1) :5-8
URL: http://jros.iums.ac.ir/article-1-2316-en.html
URL: http://jros.iums.ac.ir/article-1-2316-en.html
1- Department of Orthopedic Surgery, Rasoul-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract: (335 Views)
Knee osteoarthritis (KOA) is increasingly recognized as a disease driven by low-grade inflammation in addition to mechanical degeneration. Among immune cells involved in joint homeostasis, synovial macrophages play a central role in modulating inflammatory responses. Recent evidence highlights the importance of macrophage polarization, particularly the imbalance between pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes, in the progression of KOA. This narrative mini-review summarizes current insights into the role of synovial macrophage polarization in KOA, its molecular regulation, and its potential as a therapeutic target.
Type of Study: Review Paper |
Subject:
Knee surgery
Received: 2025/05/22 | Accepted: 2025/12/5 | Published: 2026/01/1
Received: 2025/05/22 | Accepted: 2025/12/5 | Published: 2026/01/1
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