Volume 13, Issue 1 (Winter-In Press 2026)
JROS 2026, 13(1): 0-0 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
mokhtari K. Molecular and Cellular Mechanisms of Intervertebral Disc Degeneration: A Narrative Mini-Review. JROS 2026; 13 (1)
URL: http://jros.iums.ac.ir/article-1-2324-en.html
URL: http://jros.iums.ac.ir/article-1-2324-en.html
Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (6 Views)
Intervertebral disc degeneration (IVDD) is a major contributor to low back pain and spinal disorders, representing a significant global health burden. Once considered a consequence of aging and mechanical stress, IVDD is now recognized as a multifactorial process involving complex molecular and cellular mechanisms. This narrative mini-review summarizes current insights into the pathophysiology of IVDD, focusing on inflammatory signaling, extracellular matrix degradation, oxidative stress, mitochondrial dysfunction, and cellular senescence. Understanding these interconnected pathways provides a foundation for the development of targeted and regenerative therapeutic strategies.
Keywords: Disc degeneration, Low back pain, Inflammatory signaling, Extracellular matrix degradation
Type of Study: Review Paper |
Subject:
Spine surgery
Received: 2026/05/4 | Accepted: 2026/05/4 | Published: 2026/02/24
Received: 2026/05/4 | Accepted: 2026/05/4 | Published: 2026/02/24
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
Copyright © The Author(s);
This is an open access article distributed under the terms of the Creative Commons Attribution License (CC-By-NC), which permits use, distribution, and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Contact Information
