Volume 10, Issue 2 (In-Press 2023)
JROS 2023, 10(2): 0-0 |
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Nakhaei Amroodi M, Bahaeddini M, Amiri S, Karimi M, Mokhtari K, Tabrizian P. Insights into Gene Therapy Innovations for Orthopedic Disorders: A Mini-Review. JROS 2023; 10 (2)
URL: http://jros.iums.ac.ir/article-1-2241-en.html
URL: http://jros.iums.ac.ir/article-1-2241-en.html
Morteza Nakhaei Amroodi1 
, Mohammadreza Bahaeddini1 , Saeedreza Amiri1 , Mansour Karimi1 , Khatere Mokhtari2 , Pouria Tabrizian 1
, Mohammadreza Bahaeddini1 , Saeedreza Amiri1 , Mansour Karimi1 , Khatere Mokhtari2 , Pouria Tabrizian 1
1- Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Department of Orthopedic, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
2- Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (69 Views)
A thorough examination of existing scholarly works pertaining to the utilization of gene therapy for addressing orthopedic disorders was undertaken. The review underscores the considerable promise of gene therapy in transforming clinical practices within this domain. Orthopedic conditions, encompassing a spectrum of issues such as spinal fusion failure, disc degeneration, fractures, segmental bone defects, bone tumors, articular disorders, soft-tissue injuries, genetic disorders, and nerve and muscular disorders, frequently present challenges for conventional surgical or medical approaches. Consequently, there has been a concerted effort to explore gene therapy as a viable alternative avenue for intervention. Significant progress has been achieved in this innovative approach, although several hurdles must be addressed before its widespread clinical application in humans. Nonetheless, it is evident that gene therapy holds immense promise as a valuable treatment modality for orthopedic disorders in the twenty-first century. As gene transfer techniques continue to advance, the potential applications of gene therapy in orthopedic disorders are expected to expand significantly.
Keywords: Gene Therapy, Orthopedic, spinal fusion failure, bone tumors, genetic disorders, muscular disorders
Type of Study: Review Paper |
Subject:
Shoulder / Elbow
Received: 2024/05/1 | Accepted: 2024/06/19 | Published: 2023/05/8
Received: 2024/05/1 | Accepted: 2024/06/19 | Published: 2023/05/8
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