Volume 10, Issue 2 (5-2023)
JROS 2023, 10(2): 53-66 |
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Nakhaei Amroodi M, Bahaeddini M, Amiri S, Karimi M, Mokhtari K, Tabrizian P. Insights Into Gene Therapy Innovations for Orthopedic Disorders: A Mini-review. JROS 2023; 10 (2) :53-66
URL: http://jros.iums.ac.ir/article-1-2241-en.html
URL: http://jros.iums.ac.ir/article-1-2241-en.html
Morteza Nakhaei Amroodi1 
, Mohammadreza Bahaeddini1 , Saeedreza Amiri1 , Mansour Karimi1 , Khatere Mokhtari2 , Pouria Tabrizian 1
, Mohammadreza Bahaeddini1 , Saeedreza Amiri1 , Mansour Karimi1 , Khatere Mokhtari2 , Pouria Tabrizian 1
1- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Shafayahyaeian Hospital, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
2- Department of Cellular and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
Abstract: (242 Views)
A thorough review of the available scientific works related to the use of gene therapy to address orthopedic disorders was performed. This review highlights the considerable promise of gene therapy in transforming clinical practice in this domain. Orthopedic conditions, including a range of problems, such as spinal fusion failure, disc degeneration, fractures, segmental bone defects, bone tumors, joint disorders, soft-tissue injuries, genetic disorders, and nerve and muscle disorders, often pose significant challenges for traditional surgical or medical treatments. Consequently, a concerted effort has been made to explore gene therapy as a viable alternative. This innovative approach has made significant progress, although several hurdles must be addressed before widespread clinical application in humans. However, gene therapy has considerable potential as a promising treatment option for orthopedic disorders in the 21st century. As gene transfer techniques continue to advance, the potential applications of gene therapy for orthopedic disorders are expected to expand significantly.
Keywords: Gene therapy, Orthopedics, Spinal fusion failure, Bone tumors, Genetic disorders, Muscular disorders
Type of Study: Review Paper |
Subject:
Shoulder / Elbow
Received: 2022/05/1 | Accepted: 2022/06/19 | Published: 2023/05/1
Received: 2022/05/1 | Accepted: 2022/06/19 | Published: 2023/05/1
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