Volume 13, Issue 1 (Winter 2026)
JROS 2026, 13(1): 9-12 |
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Moeini J, Shakeri M, Chehrassan M R, Shakeri Sefat A. Biological Mechanisms Underlying Kyphosis: A Narrative Mini-review of Spinal Deformity Beyond Mechanics. JROS 2026; 13 (1) :9-12
URL: http://jros.iums.ac.ir/article-1-2318-en.html
URL: http://jros.iums.ac.ir/article-1-2318-en.html
1- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
2- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. & Department of Spine Surgery, Baqiyatallah University of Medical Sciences, Tehran, Iran.
2- Department of Orthopedics, Bone and Joint Reconstruction Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. & Department of Spine Surgery, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Abstract: (320 Views)
Kyphosis is traditionally described as excessive curvature of the thoracic spine, often attributed to structural and biomechanical abnormalities. However, emerging evidence suggests that biological and molecular mechanisms also contribute to its development and progression. This narrative mini-review explores the underlying biological factors associated with kyphosis, including alterations in vertebral growth plate, extracellular matrix remodeling, inflammatory pathways, and muscle degeneration. Understanding these mechanisms provides new insights into the pathophysiology of kyphotic deformities and may inform future therapeutic strategies.
Type of Study: Review Paper |
Subject:
Spine surgery
Received: 2025/12/1 | Accepted: 2026/01/10 | Published: 2026/01/1
Received: 2025/12/1 | Accepted: 2026/01/10 | Published: 2026/01/1
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