Volume 13, Issue 1 (Winter-In Press 2026)
JROS 2026, 13(1): 0-0 |
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Moeini J, Shakeri M, Chehrassan M R, Shakeri Sefat A. Biological Mechanisms Underlying Kyphosis: A Narrative Mini-Review of Spinal Deformity Beyond Mechanics. JROS 2026; 13 (1)
URL: http://jros.iums.ac.ir/article-1-2318-en.html
URL: http://jros.iums.ac.ir/article-1-2318-en.html
1- Bone and Joint Reconstruction Research Center, Department of Orthopedics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Abstract: (9 Views)
Kyphosis is traditionally described as an excessive curvature of the thoracic spine, often attributed to structural and biomechanical abnormalities. However, emerging evidence suggests that biological and molecular mechanisms also contribute to its development and progression. This narrative mini-review explores the underlying biological factors associated with kyphosis, including vertebral growth plate alterations, extracellular matrix remodeling, inflammatory pathways, and muscle degeneration. Understanding these mechanisms provides new insights into the pathophysiology of kyphotic deformities and may inform future therapeutic strategies.
Type of Study: Review Paper |
Subject:
Spine surgery
Received: 2026/05/3 | Accepted: 2026/05/4 | Published: 2026/02/24
Received: 2026/05/3 | Accepted: 2026/05/4 | Published: 2026/02/24
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